Wednesday, June 25, 2008

Real and Apparent Danger

By Angry Doc

There is a real and apparent danger in Singapore.

(emphasis mine)

Toxins in dish-washing detergent?

I WOULD like to ask why dish-washing liquid detergents do not carry ingredient labels. This is perhaps an oversight since such detergents leave traces on utensils, even after washing.

The danger is even more apparent in foodcourts where mass-washed utensils are coated with unknown ingredients.

Recently, there were reports about the danger of methylisothiazolinone, a neurotoxin that is found increasingly in shampoos, except some old, trusted brands. Methylisothiazolinone is possibly found in dish-washing detergent, especially those that tout 'anti-bacteria' formula since methylisothiazolinone is also a biocide.

Likewise, can the authorities clarify why formaldehyde is found increasingly in shampoos? The dangers of formaldehyde are already known, such as autism, eyesight degeneration and high carcinogenic effect on contact with water molecules. In addition, there are no standards as to how much formaldehyde is added to shampoo since it is considered a non-food item. But the danger is real and apparent.

Michael Yee

angry doc won't address the first part of Mr Yee's letter, since he too does not want detergent in his food. But the second part of the letter gets to him.

Formaldehyde is a widely used form of preservative. No doubt it can be fatal when ingested, and causes irritation of the eyes and skin when in vapour form (angry doc had personal experience of that back in medical school, he does - ah, sweet, gross anatomy!). But is it as dangerous as Mr Yee described?

Does formaldehyde cause eyesight degeneration? Well, yes, if it is splashed into your eye or injected into an eyeball.

Does it have high carcinogenic effect? Well, yes, it has been shown to cause some forms of cancers in mice, but it has not been shown to cause more cancers in people who are exposed to it at work (and who presumably use shampoo when they are off work).

Does it cause autism? angry doc couldn't find any evidence for that.

Mr Yee has given misleading information about the dangers of formaldehyde in the first part of that paragraph, but the penultimate sentence in that paragraph is simply untrue.

Shampoos are classified as cosmetic products, and come under the purview of the Cosmetics Control Unit of the Health Products Regulation Group of the Health Sciences Authority. The amount of formaldehyde permitted in shampoos is regulated by the ASEAN Cosmetic Directive, at the concentration of no more than 0.2%. Shampoos manufactured by Unilever contain formaldehyde of 0.04%. There is no evidence that at that concentration, application of formaldehyde to the skin for short durations causes any of the harmful effects Mr Yee mentioned.

Formaldehyde is a toxin in the commonly used sense of the word, but to say that shampoos can cause cancers, eyesight degeneration and autism, and that the authorities are not doing anything about it is dishonest and irresponsible.

The fact is information about regulations on the amount of formaldehyde permitted in shampoos and the dangers of formaldehyde is available on the internet if one would just search for them. Mr Yee had apparently not done so before sending in his alarmist letter, and the ST Forum editor has in angry doc's opinion lapsed in his duty by publishing it. This lack of editorial rigour is the real and apparent danger.

5 comments:

Rich Murray said...

re "A Few too Many", Joan Acocella, The New Yorker, long review of hangover
research 2008.05.26 -- same levels of formaldehyde and formic acid in FEMA
trailers and other sources (aspartame, dark wines and liquors, tobacco
smoke): Murray 2008.06.05
http://rmforall.blogspot.com/2008_06_01_archive.htm
Thursday, June 5, 2008
http://groups.yahoo.com/group/aspartameNM/message/1541


formaldehyde and formic acid in FEMA trailers and other sources (aspartame,
dark wines and liquors, tobacco smoke): Murray 2008.01.30
http://rmforall.blogspot.com/2008_01_01_archive.htm
Wednesday, January 30, 2008
http://groups.yahoo.com/group/aspartameNM/message/1508

The FEMA trailers give about the same amount of formaldehyde and formic acid
daily as from a quart of dark wine or liquor, or two quarts (6 12-oz cans)
of aspartame diet soda, from their over 1 tenth gram methanol impurity (one
part in 10,000), which the body quickly makes into formaldehyde and then
formic acid -- enough to be the major cause of "morning after" alcohol
hangovers.

Methanol and formaldehyde and formic acid also result from many fruits and
vegetables, tobacco and wood smoke, heater and vehicle exhaust, household
chemicals and cleaners, cosmetics, and new cars, drapes, carpets, furniture,
particleboard, mobile homes, buildings, leather... so all these sources add
up and interact with many other toxic chemicals.

methanol impurity in alcohol drinks [ and aspartame ] is turned into
neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol Syndrome,
BM Kapur, DC Lehotay, PL Carlen at U. Toronto, Alc Clin Exp Res 2007 Dec.
plain text: detailed biochemistry, CL Nie et al. 2007.07.18: Murray
2008.02.24
http://rmforall.blogspot.com/2008_02_01_archive.htm
Sunday, February 24, 2008
http://groups.yahoo.com/group/aspartameNM/message/1524

"Of course, everyone chooses, as a natural priority, to enjoy peace, joy,
and love by helping to find, quickly share, and positively act upon evidence
about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@comcast.net
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://RMForAll.blogspot.com new primary archive

http://groups.yahoo.com/group/aspartameNM/messages
group with 125 members, 1,541 posts in a public archive

http://groups.yahoo.com/group/aspartame/messages
group with 1,109 members, 22,714 posts in public archive

http://www.newyorker.com/reporting/2008/05/26/080526fa_fact_acocella?currentPage=all

Annals Of Drinking
A Few Too Many
Is there any hope for the hung over?
by Joan Acocella May 26, 2008 themail@newyorker.com

"Wayne Jones, of the Swedish National Laboratory of Forensic Medicine"
[ http://groups.yahoo.com/group/aspartameNM/message/1469
highly toxic formaldehyde, the cause of alcohol hangovers, is
made by the body from 100 mg doses of methanol from
dark wines and liquors, dimethyl dicarbonate, and aspartame:
Murray 2007.08.31 ]

http://groups.yahoo.com/group/aspartameNM/message/1286
methanol products (formaldehyde and formic acid) are main cause
of alcohol hangover symptoms [same as from similar amounts of
methanol, the 11% part of aspartame]: YS Woo et al, 2005 Dec:
Murray 2006.01.20

Addict Biol. 2005 Dec;10(4): 351-5.
Concentration changes of methanol in blood samples during
an experimentally induced alcohol hangover state.
Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT, Kim DJ.
Chuncheon National Hospital, Department of Psychiatry,
The Catholic University of Korea, Seoul, Korea.
http://www.cuk.ac.kr/eng/ sysop@catholic.ac.kr
Songsin Campus: 02-740-9714 Songsim Campus: 02-2164-4116
Songeui Campus: 02-2164-4114
http://www.cuk.ac.kr/eng/sub055.htm eight hospitals

[ Han-Kyu Lee ]

A hangover is characterized by the unpleasant physical and mental
symptoms that occur between 8 and 16 hours after drinking alcohol.

After inducing experimental hangover in normal individuals,
we measured the methanol concentration prior to
and after alcohol consumption
and we assessed the association between the hangover condition
and the blood methanol level.

A total of 18 normal adult males participated in this study.

They did not have any previous histories of psychiatric
or medical disorders.

The blood ethanol concentration prior to the alcohol intake
(2.26+/-2.08) was not significantly different from that
13 hours after the alcohol consumption (3.12+/-2.38).

However, the difference of methanol concentration
between the day of experiment (prior to the alcohol intake)
and the next day (13 hours after the alcohol intake)
was significant (2.62+/-1.33/l vs. 3.88+/-2.10/l, respectively).

A significant positive correlation was observed
between the changes of blood methanol concentration
and hangover subjective scale score increment when covarying
for the changes of blood ethanol level (r=0.498, p<0.05).

This result suggests the possible correlation of methanol
as well as its toxic metabolite to hangover. PMID: 16318957

[ The toxic metabolite of methanol is formaldehyde, which in turn
partially becomes formic acid -- both potent cumulative toxins
that are the actual cause of the toxicity of methanol.]

This study by Jones AW (1987) found next-morning hangover
from red wine with 100 to 150 mg methanol
(9.5 % w/v ethanol, 100 mg/l methanol, 0.01 %).
Fully 11% of aspartame is methanol --
1,120 mg aspartame in 2 L diet soda,
almost six 12-oz cans, gives 123 mg methanol (wood alcohol).

Pharmacol Toxicol. 1987 Mar; 60(3): 217-20.
Elimination half-life of methanol during hangover.
Jones AW. wayne.jones@RMV.se;
Department of Forensic Toxicology,
University Hospital, SE-581 85 Linkoping, Sweden.

This paper reports the elimination half-life of methanol in human
volunteers.
Experiments were made during the morning after the subjects had
consumed 1000-1500 ml red wine
(9.5 % w/v ethanol, 100 mg/l methanol)
the previous evening. [ 100 to 150 mg methanol ]
The washout of methanol from the body
coincided with the onset of hangover.
The concentrations of ethanol and methanol in blood were
determined indirectly by analysis of end-expired alveolar air.
In the morning when blood-ethanol dropped
below the Km of liver alcohol dehydrogenase (ADH)
of about 100 mg/l (2.2 mM),
the disappearance half-life of ethanol was 21, 22, 18 and 15 min.
in 4 test subjects respectively.
The corresponding elimination half-lives of methanol
were 213, 110, 133 and 142 min. in these same individuals.
The experimental design outlined in this paper can be used
to obtain useful data on elimination kinetics of methanol
in human volunteers without undue ethical limitations.
Circumstantial evidence is presented to link methanol
or its toxic metabolic products, formaldehyde and formic acid,
with the pathogenesis of hangover. PMID: 3588516 ]
[ for more, use initial URL..... ]

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